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RAS PhysiologyЖурнал эволюционной биохимии и физиологии Journal of Evolutionary Biochemistry and Physiology

  • ISSN (Print) 0044-4529
  • ISSN (Online) 3034-5529

Mechanical alternancies in cardiomycytes of the myocardial sleeves of the superior vena cava and pulmonary veins as a potential source of ectopic activity of the atria

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PII
S0044452925020044-1
DOI
10.31857/S0044452925020044
Publication type
Article
Status
Published
Authors
T. A. Myachina
  • Affiliation: Institute of Immunology and Physiology, Ural branch of Russian Academy of Sciences
Volume/ Edition
Volume 61 / Issue number 2
Pages
108-118
Abstract
The myocardium of the right and left atria (RA and LA) continues into the superior vena cava (SVC) and pulmonary veins (PV) and forms myocardial sleeves, which are sources of ectopic activity causing atrial fibrillation. We compared the sarcomere dynamics of single cardiomyocytes from the myocardial sleeves of the SVC and PV and guinea pig atria. SVC cardiomyocytes were characterized by a longer time to peak sarcomere shortening and time to 50% relaxation than cardiomyocytes of other groups. In cardiomyocytes of the SVC, PV and right atrium, there was no correlation between the amplitude of sarcomere shortening and the length of the cardiomyocytes. The sarcomere shortening alternans was found in cardiomyocytes of the SVC and PV. The mechanical alternans and the lack of correlation between the amplitude of the sarcomere shortening and the cell size in the myocardial sleeves of the SVC and PV may point to a mechanical substrate that provokes arrhythmia.
Keywords
миокардиальные рукава кардиомиоциты верхней полой вены кардиомиоциты легочной вены укорочение-расслабление саркомеров механические альтернансы фибрилляция предсердий
Date of publication
18.09.2025
Year of publication
2025
Number of purchasers
0
Views
3

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